Human telomerase reverse transcriptase and glucose-regulated protein 78 increase the life span of articular chondrocytes and their repair potential

BACKGROUND: Like all mammalian cells, normal adult chondrocytes have a limited replicative life span, which decreases with age. To facilitate the therapeutic use of chondrocytes from older donors, a method is needed to prolong their life span. METHODS: We transfected chondrocytes with hTERT or GRP78...

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Main Authors: Sato, Masato, Shin-ya, Kazuo, Lee, Jeong Ik, Ishihara, Miya, Nagai, Toshihiro, Kaneshiro, Nagatoshi, Mitani, Genya, Tahara, Hidetoshi, Mochida, Joji
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349494/
https://ncbi.nlm.nih.gov/pubmed/22472071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2474-13-51
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