The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells

BACKGROUND: Inhibitors of nicotinamide phosphoribosyltransferase have recently been validated as therapeutic targets in leukemia, but the mechanism of leukemogenic transformation downstream of this enzyme is unclear. DESIGN AND METHODS: Here, we evaluated whether nicotinamide phosphoribosyltransfera...

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Bibliographische Detailangaben
Hauptverfasser: Dan, Lan, Klimenkova, Olga, Klimiankou, Maxim, Klusman, Jan-Henning, van den Heuvel-Eibrink, Marry M., Reinhardt, Dirk, Welte, Karl, Skokowa, Julia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2012
Schlagworte:
Original Articles and Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347680/
https://ncbi.nlm.nih.gov/pubmed/22207684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.055236
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