Retinol-Binding Protein 4 Inhibits Insulin Signaling in Adipocytes by Inducing Proinflammatory Cytokines in Macrophages through a c-Jun N-Terminal Kinase- and Toll-Like Receptor 4-Dependent and Retinol-Independent Mechanism

Retinol-binding protein 4 (RBP4), the sole retinol transporter in blood, is secreted from adipocytes and liver. Serum RBP4 levels correlate highly with insulin resistance, other metabolic syndrome factors, and cardiovascular disease. Elevated serum RBP4 causes insulin resistance, but the molecular m...

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Auteurs principaux: Norseen, Julie, Hosooka, Tetsuya, Hammarstedt, Ann, Yore, Mark M., Kant, Shashi, Aryal, Pratik, Kiernan, Urban A., Phillips, David A., Maruyama, Hiroshi, Kraus, Bettina J., Usheva, Anny, Davis, Roger J., Smith, Ulf, Kahn, Barbara B.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2012
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347417/
https://ncbi.nlm.nih.gov/pubmed/22431523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06193-11
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