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Nucleosome Stability Dramatically Impacts the Targeting of Somatic Hypermutation
Somatic hypermutation (SHM) of immunoglobulin (Ig) genes is initiated by the activation-induced cytidine deaminase (AID). However, the influence of chromatin on SHM remains enigmatic. Our previous cell-free studies indicated that AID cannot access nucleosomal DNA in the absence of transcription. We...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3347409/ https://ncbi.nlm.nih.gov/pubmed/22393257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06722-11 |
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