Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Targeting the Interaction between Vif and ElonginC

The HIV-1 viral infectivity factor (Vif) protein is essential for viral replication. Vif recruits cellular ElonginB/C-Cullin5 E3 ubiquitin ligase to target the host antiviral protein APOBEC3G (A3G) for proteasomal degradation. In the absence of Vif, A3G is packaged into budding HIV-1 virions and int...

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Detalhes bibliográficos
Main Authors: Zuo, Tao, Liu, Donglai, Lv, Wei, Wang, Xiaodan, Wang, Jiawen, Lv, Mingyu, Huang, Wenlin, Wu, Jiaxin, Zhang, Haihong, Jin, Hongwei, Zhang, Liangren, Kong, Wei, Yu, Xianghui
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347289/
https://ncbi.nlm.nih.gov/pubmed/22379088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06957-11
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