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Targeting Synthetic Lethal Interactions between Myc and the eIF4F Complex Impedes Tumorigenesis
The energetically demanding process of translation is linked to multiple signalling events through mTOR mediated regulation of eukaryotic initiation factor (eIF) 4F complex assembly. Disrupting mTOR constraints on eIF4F activity can be oncogenic and alter chemotherapy response, making eIF4F an attra...
में बचाया:
| मुख्य लेखकों: | , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2012
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3346676/ https://ncbi.nlm.nih.gov/pubmed/22573234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.02.010 |
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