Induction of Oxidative Stress in Trypanosoma brucei by the Antitrypanosomal Dihydroquinoline OSU-40

Dihydroquinoline derivative OSU-40 (1-benzyl-1,2-dihydro-2,2,4-trimethylquinolin-6-yl acetate) is selectively potent against Trypanosma brucei rhodesiense in vitro (50% inhibitory concentration [IC(50)], 14 nM; selectivity index, 1,700) and has been proposed to cause the formation of reactive oxygen...

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Detaylı Bibliyografya
Asıl Yazarlar: He, Shanshan, Dayton, Alex, Kuppusamy, Periannan, Werbovetz, Karl A., Drew, Mark E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2012
Konular:
Mechanisms of Action: Physiological Effects
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346584/
https://ncbi.nlm.nih.gov/pubmed/22314522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06386-11
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