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Developmental Truncations of Connexin 50 by Caspases Adaptively Regulate Gap Junctions/Hemichannels and Protect Lens Cells against Ultraviolet Radiation

The gap junction-forming connexin (Cx) 50 is truncated gradually during lens development. Premature cleavage of lens connexins is thought to be associated with cataract formation. We have shown previously that Cx50 is likely to be cleaved by caspase-3 like protease during chick lens development. Her...

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Main Authors: Wang, Ke, Gu, Sumin, Yin, Xinye, Weintraub, Susan T., Hua, Zichun, Jiang, Jean X.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346145/
https://ncbi.nlm.nih.gov/pubmed/22418432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.313171
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