The association of C3435T single-nucleotide polymorphism, Pgp-glycoprotein gene expression levels and carbamazepine maintenance dose in patients with epilepsy

The ABCB1 gene encodes the P-glycoprotein (Pgp) protein, which is thought to transport various antiepileptic drugs. The single nucleotide polymorphism (SNP) (C3435T) in exon 26 of this gene correlates with the altered expression levels of P-glycoprotein, range of drug response and clinical condition...

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Autori principali: Sterjev, Zoran, Trencevska, Gordana Kiteva, Cvetkovska, Emilija, Petrov, Igor, Kuzmanovski, Igor, Ribarska, Jasmina T, Nestorovska, Aleksandra K, Matevska, Nadica, Naumovska, Zorica, Jolevska-Trajkovic, Suzana, Dimovski, Aleksandar, Suturkova, Ljubica
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2012
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346059/
https://ncbi.nlm.nih.gov/pubmed/22570551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/NDT.S28285
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