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Designing cyclopentapeptide inhibitor as potential antiviral drug for dengue virus ns5 methyltransferase

NS5 methyltransferase (Mtase) has a crucial role in the replication of dengue virus. There are two active sites on NS5 Mtase i.e., SAM and RNA-cap binding sites. Inhibition of the NS5 Mtase activity is expected to prevent the propagation of dengue virus. This study was conducted to design cyclic pep...

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מידע ביבליוגרפי
Main Authors: Idrus, Syarifuddin, Tambunan, Usman Sumo Friend, Zubaidi, Ahmad Ardilla
פורמט: Artigo
שפה:Inglês
יצא לאור: Biomedical Informatics 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346019/
https://ncbi.nlm.nih.gov/pubmed/22570514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6026/97320630008348
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