Identification of multiple quantitative trait loci linked to prion disease incubation period in mice

Polymorphisms in the prion protein gene are known to affect prion disease incubation times and susceptibility in humans and mice. However, studies with inbred lines of mice show that large differences in incubation times occur even with the same amino acid sequence of the prion protein, suggesting t...

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Bibliographische Detailangaben
Hauptverfasser: Lloyd, Sarah E., Onwuazor, Obia N., Beck, Jonathan A., Mallinson, Gary, Farrall, Martin, Targonski, Paul, Collinge, John, Fisher, Elizabeth M. C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC33459/
https://ncbi.nlm.nih.gov/pubmed/11353827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.101130398
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