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Characterization and localization of cis-diamminedichloro-platinum(II) adducts on a purified oligonucleotide containing the codons 12 and 13 of H-ras proto-oncogene.

The use of substrates containing well defined adducts at precise sites, is required to perform a careful analysis of the toxic and mutagenic potential of a lesion. As a first step in this direction the octamer 5'-d(CCGGCGGT), containing the sequence of the codons 12 d(GGC) and 13 d(GGT) of the...

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Detalhes bibliográficos
Main Authors: Pillaire, M J, Villani, G, Hoffmann, J S, Mazard, A M, Defais, M
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC334560/
https://ncbi.nlm.nih.gov/pubmed/1480469
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