Long-lived epithelial immunity by tissue-resident memory T (T(RM)) cells in the absence of persisting local antigen presentation

Although circulating memory T cells provide enhanced protection against pathogen challenge, they often fail to do so if infection is localized to peripheral or extralymphoid compartments. In those cases, it is T cells already resident at the site of virus challenge that offer superior immune protect...

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Main Authors: Mackay, Laura K., Stock, Angus T., Ma, Joel Z., Jones, Claerwen M., Kent, Stephen J., Mueller, Scott N., Heath, William R., Carbone, Francis R., Gebhardt, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344960/
https://ncbi.nlm.nih.gov/pubmed/22509047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202288109
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