Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission

Synaptic transmission depends critically on the Sec1p/Munc18 protein Munc18-1, but it is unclear whether Munc18-1 primarily operates as a integral part of the fusion machinery or has a more upstream role in fusion complex assembly. Here, we show that point mutations in Munc18-1 that interfere with b...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Meijer, Marieke, Burkhardt, Pawel, de Wit, Heidi, Toonen, Ruud F, Fasshauer, Dirk, Verhage, Matthijs
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343470/
https://ncbi.nlm.nih.gov/pubmed/22446389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.72
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller