HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition

The function of metabolic state in stemness is poorly understood. Mouse embryonic stem cells (ESC) and epiblast stem cells (EpiSC) are at distinct pluripotent states representing the inner cell mass (ICM) and epiblast embryos. Human embryonic stem cells (hESC) are similar to EpiSC stage. We now show...

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Autori principali: Zhou, Wenyu, Choi, Michael, Margineantu, Daciana, Margaretha, Lilyana, Hesson, Jennifer, Cavanaugh, Christopher, Blau, C Anthony, Horwitz, Marshall S, Hockenbery, David, Ware, Carol, Ruohola-Baker, Hannele
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343469/
https://ncbi.nlm.nih.gov/pubmed/22446391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.71
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