Maintenance of caspase-3 proenzyme dormancy by an intrinsic “safety catch” regulatory tripeptide

Caspase-3 is synthesized as a dormant proenzyme and is maintained in an inactive conformation by an Asp-Asp-Asp “safety-catch” regulatory tripeptide contained within a flexible loop near the large-subunit/small-subunit junction. Removal of this “safety catch” results in substantially enhanced autoca...

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Detalhes bibliográficos
Main Authors: Roy, Sophie, Bayly, Christopher I., Gareau, Yves, Houtzager, Vicky M., Kargman, Stacia, Keen, Sabina L. C., Rowland, Kathleen, Seiden, Isolde M., Thornberry, Nancy A., Nicholson, Donald W.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC33434/
https://ncbi.nlm.nih.gov/pubmed/11353841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.111085198
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