Oxaliplatin-induced neurotoxicity involves TRPM8 in the mechanism of acute hypersensitivity to cold sensation

Oxaliplatin-induced peripheral neurotoxicity (OPN) is commonly associated with peripheral hypersensitivity to cold sensations (CS) but the mechanism is unknown. We hypothesized that the transient receptor potential melastatin 8 (TRPM8), a putative cold and menthol receptor, contributes to oxaliplati...

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Библиографические подробности
Главные авторы: Kono, Toru, Satomi, Machiko, Suno, Manabu, Kimura, Norihisa, Yamazaki, Hirotaka, Furukawa, Hiroyuki, Matsubara, Kazuo
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Inc 2012
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343300/
https://ncbi.nlm.nih.gov/pubmed/22574275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/brb3.34
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