Mechanism of Programmed Obesity in Intrauterine Fetal Growth Restricted Offspring: Paradoxically Enhanced Appetite Stimulation in Fed and Fasting States

We have shown that intrauterine fetal growth restriction (IUGR) newborn rats exhibit hyperphagia, reduced satiety, and adult obesity. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a principal metabolic regulator that specifically regulates appetite in the hypothalamic arcuate nucl...

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Main Authors: Fukami, Tatsuya, Sun, Xiaoping, Li, Tie, Desai, Mina, Ross, Michael G.
Format: Artigo
Jezik:Inglês
Izdano: SAGE Publications 2012
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343065/
https://ncbi.nlm.nih.gov/pubmed/22344733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1933719111424448
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