Sequence-Specific Targeting of Dosage Compensation in Drosophila Favors an Active Chromatin Context

The Drosophila MSL complex mediates dosage compensation by increasing transcription of the single X chromosome in males approximately two-fold. This is accomplished through recognition of the X chromosome and subsequent acetylation of histone H4K16 on X-linked genes. Initial binding to the X is thou...

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Hauptverfasser: Alekseyenko, Artyom A., Ho, Joshua W. K., Peng, Shouyong, Gelbart, Marnie, Tolstorukov, Michael Y., Plachetka, Annette, Kharchenko, Peter V., Jung, Youngsook L., Gorchakov, Andrey A., Larschan, Erica, Gu, Tingting, Minoda, Aki, Riddle, Nicole C., Schwartz, Yuri B., Elgin, Sarah C. R., Karpen, Gary H., Pirrotta, Vincenzo, Kuroda, Mitzi I., Park, Peter J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343056/
https://ncbi.nlm.nih.gov/pubmed/22570616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002646
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