Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics

BACKGROUND: The heat shock protein 90 (Hsp90) is required for the stability of many signalling kinases. As a target for cancer therapy it allows the simultaneous inhibition of several signalling pathways. However, its inhibition in healthy cells could also lead to severe side effects. This is the fi...

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Bibliografiske detaljer
Main Authors: Haupt, Armin, Joberty, Gerard, Bantscheff, Marcus, Fröhlich, Holger, Stehr, Henning, Schweiger, Michal R, Fischer, Axel, Kerick, Martin, Boerno, Stefan T, Dahl, Andreas, Lappe, Michael, Lehrach, Hans, Gonzalez, Cayetano, Drewes, Gerard, Lange, Bodo MH
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342885/
https://ncbi.nlm.nih.gov/pubmed/22277058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-38
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