Synthesis and anti-HSV-1 evaluation of new 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridines and 3H-pyrido[2,3-b]pyrazolo[3,4-h]-1,6-naphthyridines

BACKGROUND: Herpes simplex virus type-1 (HSV-1) is the primary cause of facial lesions (mouth, lips, and eyes) in humans. The widespread use of acyclovir and nucleoside analogues has led to emergence of HSV strains that are resistant to these drugs. Recently, non-nucleoside anti-HSV compounds have r...

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Dettagli Bibliografici
Autori principali: Bernardino, Alice MR, Azevedo, Alexandre R, Pinheiro, Luiz CS, Borges, Júlio C, Paixão, Izabel CP, Mesquita, Milene, Souza, Thiago ML, dos Santos, Maurício S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342845/
https://ncbi.nlm.nih.gov/pubmed/22373524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2191-2858-2-3
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