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Insertion of the B2 sequence into intron 13 is the only defect of the H-2k C4 gene which causes low C4 production.
The serum level of the fourth component of complement (C4) in mice bearing H-2k haplotype is only 1/10 of that of non-H-2k mice. H-2k bearing mice, but not non-H-2k bearing mice, have an insertion of the B2 sequence into intron 13 of the C4 gene, and aberrant C4 mRNA in liver apparently generated by...
Bewaard in:
| Hoofdauteurs: | , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
1992
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC334272/ https://ncbi.nlm.nih.gov/pubmed/1329034 |
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