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Identity by Descent Mapping of Founder Mutations in Cancer Using High-Resolution Tumor SNP Data
Dense genotype data can be used to detect chromosome fragments inherited from a common ancestor in apparently unrelated individuals. A disease-causing mutation inherited from a common founder may thus be detected by searching for a common haplotype signature in a sample population of patients. We pr...
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| Główni autorzy: | , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Public Library of Science
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3342326/ https://ncbi.nlm.nih.gov/pubmed/22567117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035897 |
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