Identity by Descent Mapping of Founder Mutations in Cancer Using High-Resolution Tumor SNP Data

Dense genotype data can be used to detect chromosome fragments inherited from a common ancestor in apparently unrelated individuals. A disease-causing mutation inherited from a common founder may thus be detected by searching for a common haplotype signature in a sample population of patients. We pr...

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Autori principali: Letouzé, Eric, Sow, Aliou, Petel, Fabien, Rosati, Roberto, Figueiredo, Bonald C., Burnichon, Nelly, Gimenez-Roqueplo, Anne-Paule, Lalli, Enzo, de Reyniès, Aurélien
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342326/
https://ncbi.nlm.nih.gov/pubmed/22567117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035897
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