PI3K/Akt signalling is required for the attachment and spreading, and growth in vivo of metastatic scirrhous gastric carcinoma

BACKGROUND: PI3K/Akt (PKB) pathway has been shown in several cell types to be activated by ligands to cell surface integrins, leading to the metastasis of tumour cells. The signalling pathways involved in the metastatic spread of human scirrhous gastric carcinoma cells have not been defined. METHODS...

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Bibliografiske detaljer
Main Authors: Matsuoka, T, Yashiro, M, Nishioka, N, Hirakawa, K, Olden, K, Roberts, J D
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Molecular Diagnostics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341864/
https://ncbi.nlm.nih.gov/pubmed/22531720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.107
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