Repair and replication of plasmids with site-specific 8-oxodG and 8-AAFdG residues in normal and repair-deficient human cells.

The in vivo mutagenicity of 7-hydro-8-oxo-2'-deoxyguanosine (8-oxodG) and N-(guanin-8-yl)-N-acetyl-2-aminofluorene (8-AAFdG) in human cells was determined by transfecting various cell lines with plasmids that carried a single adduct at a defined site. 8-OxodG is one of the many DNA modification...

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Dettagli Bibliografici
Autori principali: Klein, J C, Bleeker, M J, Saris, C P, Roelen, H C, Brugghe, H F, van den Elst, H, van der Marel, G A, van Boom, J H, Westra, J G, Kriek, E
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1992
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC334169/
https://ncbi.nlm.nih.gov/pubmed/1408745
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