Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase-1

AIMS: Endothelial dysfunction is a hallmark of preeclampsia. Desensitization of the phosphoinositide 3-kinase (PI3K)/Akt pathway underlies endothelial dysfunction and haeme oxygenase-1 (HO-1) is decreased in preeclampsia. To identify therapeutic targets, we sought to assess whether these two regulat...

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Autori principali: Cudmore, Melissa J., Ahmad, Shakil, Sissaoui, Samir, Ramma, Wenda, Ma, Bin, Fujisawa, Takeshi, Al-Ani, Bahjat, Wang, Keqing, Cai, Meng, Crispi, Fatima, Hewett, Peter W., Gratacós, Eduard, Egginton, Stuart, Ahmed, Asif
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
Soggetti:
Basic Science
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341632/
https://ncbi.nlm.nih.gov/pubmed/21411816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehr065
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