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Reflex Immunohistochemistry and Microsatellite Instability Testing of Colorectal Tumors for Lynch Syndrome Among US Cancer Programs and Follow-Up of Abnormal Results

PURPOSE: Immunohistochemistry (IHC) for MLH1, MSH2, MSH6, and PMS2 protein expression and microsatellite instability (MSI) are well-established tools to screen for Lynch syndrome (LS). Although many cancer centers have adopted these tools as reflex LS screening after a colorectal cancer diagnosis, t...

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Detalhes bibliográficos
Main Authors: Beamer, Laura C., Grant, Marcia L., Espenschied, Carin R., Blazer, Kathleen R., Hampel, Heather L., Weitzel, Jeffrey N., MacDonald, Deborah J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341150/
https://ncbi.nlm.nih.gov/pubmed/22355048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2011.38.4719
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