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Mislocalization and Degradation of Human P23H-Rhodopsin-GFP in a Knockin Mouse Model of Retinitis Pigmentosa

PURPOSE. To engineer a knockin mouse model that can be used to monitor the effects of treatments on degradation and mislocalization of proline-to-histidine change at codon 23 (P23H) rhodopsin, a common cause of autosomal dominant retinitis pigmentosa (ADRP). The goal was to introduce a gene that exp...

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Main Authors: Price, Brandee A., Sandoval, Ivette M., Chan, Fung, Simons, David L., Wu, Samuel M., Wensel, Theodore G., Wilson, John H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Association for Research in Vision and Ophthalmology, Inc. 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341127/
https://ncbi.nlm.nih.gov/pubmed/22110080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-8654
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