Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity

Adenosine is a potent anticonvulsant acting on excitatory synapses through A1 receptors. Cellular release of ATP, and its subsequent extracellular enzymatic degradation to adenosine, could provide a powerful mechanism for astrocytes to control the activity of neural networks during high-intensity ac...

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Autori principali: Lovatt, Ditte, Xu, Qiwu, Liu, Wei, Takano, Takahiro, Smith, Nathan A., Schnermann, Jurgen, Tieu, Kim, Nedergaard, Maiken
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341061/
https://ncbi.nlm.nih.gov/pubmed/22421436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120997109
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