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Azidothymidine and other chain terminators are mutagenic for template-switch-generated genetic mutations
The accumulation of mutations causes cell lethality and can lead to carcinogenesis. An important class of mutations, which are associated with mutational hotspots in many organisms, are those that arise by nascent strand misalignment and template-switching at the site of short repetitive sequences i...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3341039/ https://ncbi.nlm.nih.gov/pubmed/22474374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116160109 |
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