Eosinophilic Esophagitis: Epithelial Mesenchymal Transition Contributes to Esophageal Remodeling and Reverses with Treatment

BACKGROUND: Mechanisms underlying esophageal remodeling with subepithelial fibrosis in eosinophilic esophagitis (EoE) have not been delineated. OBJECTIVES: To explore a role for Epithelial Mesenchymal Transition (EMT) in EoE, and whether EMT resolves with treatment. METHODS: Esophageal biopsies from...

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Main Authors: Kagalwalla, Amir F., Akhtar, Noorain, Woodruff, Samantha A., Rea, Bryan A., Masterson, Joanne C., Mukkada, Vincent, Parashette, Kalyan R., Du, Jian, Fillon, Sophie, Protheroe, Cheryl A., Lee, James J., Amsden, Katie, Melin-Aldana, Hector, Capocelli, Kelley E., Furuta, Glenn T., Ackerman, Steven J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340537/
https://ncbi.nlm.nih.gov/pubmed/22465212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2012.03.005
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