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Newly Discovered Viral E3 Ligase pK3 Induces Endoplasmic Reticulum-associated Degradation of Class I Major Histocompatibility Proteins and Their Membrane-bound Chaperones

Viral immune invasion proteins are highly effective probes for studying physiological pathways. We report here the characterization of a new viral ubiquitin ligase pK3 expressed by rodent herpesvirus Peru (RHVP) that establishes acute and latent infection in laboratory mice. Our findings show that p...

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Detalhes bibliográficos
Main Authors: Herr, Roger A., Wang, Xiaoli, Loh, Joy, Virgin, Herbert W., Hansen, Ted H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340253/
https://ncbi.nlm.nih.gov/pubmed/22403403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.325340
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