UDP-Glucuronosyltransferase-mediated Metabolic Activation of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole

2-Amino-9H-pyrido[2,3-b]indole (AαC) is a carcinogenic heterocyclic aromatic amine (HAA) that arises in tobacco smoke. UDP-glucuronosyltransferases (UGTs) are important enzymes that detoxicate many procarcinogens, including HAAs. UGTs compete with P450 enzymes, which bioactivate HAAs by N-hydroxylat...

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Détails bibliographiques
Auteurs principaux: Tang, Yijin, LeMaster, David M., Nauwelaërs, Gwendoline, Gu, Dan, Langouët, Sophie, Turesky, Robert J.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Metabolism
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340249/
https://ncbi.nlm.nih.gov/pubmed/22393056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.320093
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