myo-Inositol Uptake Is Essential for Bulk Inositol Phospholipid but Not Glycosylphosphatidylinositol Synthesis in Trypanosoma brucei

myo-Inositol is an essential precursor for the production of inositol phosphates and inositol phospholipids in all eukaryotes. Intracellular myo-inositol is generated by de novo synthesis from glucose 6-phosphate or is provided from the environment via myo-inositol symporters. We show that in Trypan...

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Bibliographic Details
Main Authors: Gonzalez-Salgado, Amaia, Steinmann, Michael E., Greganova, Eva, Rauch, Monika, Mäser, Pascal, Sigel, Erwin, Bütikofer, Peter
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340000/
https://ncbi.nlm.nih.gov/pubmed/22351763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.344812
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