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HDAC4 regulates neuronal survival in normal and diseased retinas

Histone deacetylase 4 (HDAC4) shuttles between the nucleus and cytoplasm, and serves as a nuclear corepressor that regulates bone and muscle development. We report that HDAC4 regulates the survival of retinal neurons in the mouse in normal and pathological conditions. Reduction in HDAC4 expression d...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Bo, Cepko, Constance L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339762/
https://ncbi.nlm.nih.gov/pubmed/19131628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1166226
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