Hexavalent Chromium Cr(VI) Up-Regulates COX-2 Expression through an NFκB/c-Jun/AP-1–Dependent Pathway

Background: Hexavalent chromium [Cr(VI)] is recognized as a human carcinogen via inhalation. However, the molecular mechanisms by which Cr(VI) causes cancers are not well understood. Objectives: We evaluated cyclooxygenase-2 (COX-2) expression and the signaling pathway leading to this induction due...

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Autori principali: Zuo, Zhenghong, Cai, Tongjian, Li, Jingxia, Zhang, Dongyun, Yu, Yonghui, Huang, Chuanshu
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Institute of Environmental Health Sciences 2012
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339461/
https://ncbi.nlm.nih.gov/pubmed/22472290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1104179
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