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Trajectories of Depression Severity in Clinical Trials of Duloxetine: Insights Into Antidepressant and Placebo Responses

CONTEXT: The high percentage of failed clinical trials in depression may be due to high placebo response rates and the failure of standard statistical approaches to capture heterogeneity in treatment response. OBJECTIVE: To assess whether growth mixture modeling can provide insights into antidepress...

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Detalhes bibliográficos
Main Authors: Gueorguieva, Ralitza, Mallinckrodt, Craig, Krystal, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339151/
https://ncbi.nlm.nih.gov/pubmed/22147842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/archgenpsychiatry.2011.132
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