Exploiting a natural conformational switch to engineer an Interleukin-2 superkine

The immunostimulatory cytokine interleukin-2 (IL-2) is a growth factor for a wide range of leukocytes, including T cells and natural killer (NK) cells(1–3). Considerable effort has been invested using IL-2 as a therapeutic agent for a variety of immune disorders ranging from AIDS to cancer. However,...

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Detalhes bibliográficos
Main Authors: Levin, Aron M., Bates, Darren L., Ring, Aaron M., Krieg, Carsten, Lin, Jack T., Su, Leon, Moraga, Ignacio L., Raeber, Miro E., Bowman, Gregory R., Novick, Paul, Pande, Vijay S., Fathman, C. Garrison, Boyman, Onur, Garcia, K. Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338870/
https://ncbi.nlm.nih.gov/pubmed/22446627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10975
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