Heart Failure-Inducible Gene Therapy Targeting Protein Phosphatase 1 Prevents Progressive Left Ventricular Remodeling

BACKGROUND: The targeting of Ca(2+) cycling has emerged as a potential therapy for the treatment of severe heart failure. These approaches include gene therapy directed at overexpressing sarcoplasmic reticulum (SR) Ca(2+) ATPase, or ablation of phospholamban (PLN) and associated protein phosphatase...

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Main Authors: Miyazaki, Yosuke, Ikeda, Yasuhiro, Shiraishi, Kozo, Fujimoto, Shizuka N., Aoyama, Hidekazu, Yoshimura, Koichi, Inui, Makoto, Hoshijima, Masahiko, Kasahara, Hideko, Aoki, Hiroki, Matsuzaki, Masunori
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338799/
https://ncbi.nlm.nih.gov/pubmed/22558250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035875
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