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Sortilin Participates in Light-dependent Photoreceptor Degeneration in Vivo

Both proNGF and the neurotrophin receptor p75 (p75(NTR)) are known to regulate photoreceptor cell death caused by exposure of albino mice to intense illumination. ProNGF-induced apoptosis requires the participation of sortilin as a necessary p75(NTR) co-receptor, suggesting that sortilin may partici...

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Main Authors: Santos, Ana M., López-Sánchez, Noelia, Martín-Oliva, David, de la Villa, Pedro, Cuadros, Miguel A., Frade, José M.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338683/
https://ncbi.nlm.nih.gov/pubmed/22558402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036243
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