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Male Differentiation of Germ Cells Induced by Embryonic Age-Specific Sertoli Cells in Mice

Retinoic acid (RA) is a meiosis-inducing factor. Primordial germ cells (PGCs) in the developing ovary are exposed to RA, resulting in entry into meiosis. In contrast, PGCs in the developing testis enter mitotic arrest to differentiate into prospermatogonia. Sertoli cells express CYP26B1, an RA-metab...

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Hlavní autoři: Ohta, Kohei, Yamamoto, Miyuki, Lin, Yanling, Hogg, Nathanael, Akiyama, Haruhiko, Behringer, Richard R., Yamazaki, Yukiko
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for the Study of Reproduction, Inc 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338658/
https://ncbi.nlm.nih.gov/pubmed/22262692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.111.095943
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