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Remarkably High Rate of DNA Amplification Promoted by the Mating-Type Switching Mechanism in Schizosaccharomyces pombe

A novel mating-type switching-defective mutant showed a highly unstable rearrangement at the mating-type locus (mat1) in fission yeast. The mutation resulted from local amplification of a 134-bp DNA fragment by the mat1-switching phenomenon. We speculate that the rolling-circle-like replication and...

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Bibliografiske detaljer
Main Authors: Yu, Chuanhe, Bonaduce, Michael J., Klar, Amar J. S.
Format: Artigo
Sprog:Inglês
Udgivet: Genetics Society of America 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338267/
https://ncbi.nlm.nih.gov/pubmed/22377633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.112.138727
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