Detergents modify proteinase K resistance of PrP(Sc) in different transmissible spongiform encephalopathies (TSEs)

Prion diseases are diagnosed by the detection of their proteinase K-resistant prion protein fragment (PrP(Sc)). Various biochemical protocols use different detergents for the tissue preparation. We found that the resistance of PrP(Sc) against proteinase K may vary strongly with the detergent used. I...

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Bibliographic Details
Main Authors: Breyer, Johanna, Wemheuer, Wiebke M., Wrede, Arne, Graham, Catherine, Benestad, Sylvie L., Brenig, Bertram, Richt, Jürgen A., Schulz-Schaeffer, Walter J.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338006/
https://ncbi.nlm.nih.gov/pubmed/22226540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vetmic.2011.12.008
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