Mitochondrial Superoxide Mediates Doxorubicin-Induced Keratinocyte Apoptosis through Oxidative Modification of ERK and Bcl-2 Ubiquitination

Massive apoptosis of keratinocytes has been implicated in the pathogenesis of chemotherapy-induced skin toxicities, but the underlying mechanisms of action are not well understood. The present study investigated the apoptotic effect of doxorubicin (DOX) on HaCaT keratinocytes and determined the unde...

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Hauptverfasser: Luanpitpong, Sudjit, Chanvorachote, Pithi, Nimmannit, Ubonthip, Leonard, Stephen S., Stehlik, Christian, Wang, Liying, Rojanasakul, Yon
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337700/
https://ncbi.nlm.nih.gov/pubmed/22469513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.03.010
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