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Mitochondrial Superoxide Mediates Doxorubicin-Induced Keratinocyte Apoptosis through Oxidative Modification of ERK and Bcl-2 Ubiquitination
Massive apoptosis of keratinocytes has been implicated in the pathogenesis of chemotherapy-induced skin toxicities, but the underlying mechanisms of action are not well understood. The present study investigated the apoptotic effect of doxorubicin (DOX) on HaCaT keratinocytes and determined the unde...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3337700/ https://ncbi.nlm.nih.gov/pubmed/22469513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.03.010 |
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