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Retroviral integrase domains: DNA binding and the recognition of LTR sequences.

Integration of retroviral DNA into the host chromosome requires a virus-encoded integrase (IN). IN recognizes, cuts and then joins specific viral DNA sequences (LTR ends) to essentially random sites in host DNA. We have used computer-assisted protein alignments and mutagenesis in an attempt to local...

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Udgivet i:Nucleic Acids Res
Principais autores: Khan, E, Mack, J P, Katz, R A, Kulkosky, J, Skalka, A M
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1991
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC333721/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1850126/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/19.4.851
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