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Coming of AGE: Facile generation of attenuated vaccine strains through heterologous gene expression
Live attenuated vaccine strains for bacterial pathogens are conventionally constructed by inactivating genes important for virulence or metabolism to render the organism less virulent. Ideally, these strains follow a natural route of infection, yet elicit an immune response without causing disease....
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3337149/ https://ncbi.nlm.nih.gov/pubmed/22286696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/viru.3.1.19087 |
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