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Modified deoxyoligonucleotides stable to exonuclease degradation in serum.

Unmodified deoxyoligonucleotides are rapidly degraded in serum-containing medium. Utilizing internally labelled deoxyoligonucleotides the deoxyribonuclease profile for fetal calf serum and human serum was determined. It was found that the predominate nuclease activity in both systems was 3' exo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Shaw, J P, Kent, K, Bird, J, Fishback, J, Froehler, B
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1991
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC333706/
https://ncbi.nlm.nih.gov/pubmed/1850122
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