Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice

Current interventions for arresting autoimmune diabetes have yet to strike the balance between sufficient efficacy, minimal side effects, and lack of generalized immunosuppression. Introduction of antigen via the gut represents an appealing method for induction of antigen-specific tolerance. Here, w...

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Main Authors: Takiishi, Tatiana, Korf, Hannelie, Van Belle, Tom L., Robert, Sofie, Grieco, Fabio A., Caluwaerts, Silvia, Galleri, Letizia, Spagnuolo, Isabella, Steidler, Lothar, Van Huynegem, Karolien, Demetter, Pieter, Wasserfall, Clive, Atkinson, Mark A., Dotta, Francesco, Rottiers, Pieter, Gysemans, Conny, Mathieu, Chantal
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336982/
https://ncbi.nlm.nih.gov/pubmed/22484814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60530
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