CYP2C9 Promoter Variable Number Tandem Repeat Polymorphism Regulates mRNA Expression in Human Livers

CYP2C9 is involved in metabolism of nearly 25% of clinically used drugs. Coding region polymorphisms CYP2C9*2 and *3 contribute to interperson variability in drug dosage and clinical outcomes, whereas the role of a regulatory polymorphism remains uncertain. Measuring allelic RNA expression in 87 hum...

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Hlavní autoři: Wang, Danxin, Sun, Xiaochun, Gong, Yan, Gawronski, Brian E., Langaee, Taimour Y., Shahin, Mohamed Hossam A., Khalifa, Sherief I., Johnson, Julie A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336799/
https://ncbi.nlm.nih.gov/pubmed/22289258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.044255
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