α-Actinin-2 deficiency results in sarcomeric defects in zebrafish that cannot be rescued by α-actinin-3 revealing functional differences between sarcomeric isoforms

α-Actinins are actin-binding proteins that can be broadly divided into Ca(2+)-sensitive cytoskeletal and Ca(2+)-insensitive sarcomeric isoforms. To date, little is known about functional differences between the isoforms due to their indistinguishable activities in most in vitro assays. To identify f...

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Bibliographic Details
Main Authors: Gupta, Vandana, Discenza, Marie, Guyon, Jeffrey R., Kunkel, Louis M., Beggs, Alan H.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2012
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336783/
https://ncbi.nlm.nih.gov/pubmed/22253474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-194548
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